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目的:探讨不同血液净化方式对高脂血症性胰腺炎的治疗作用。方法:选择2016年1月-2017年6月28例高脂血症性胰腺炎患者,其中15例行血液灌流联合血液滤过治疗(HP/CVVH组),13例行血液滤过治疗(CVVH组)。比较2组患者治疗前后生命体征、APACHEⅡ评分、血浆炎性介质(TNF-α、IL-6、IL-8)及血清甘油三酯变化。结果:两组患者治疗后临床症状缓解,APACHEⅡ评分、血浆炎性介质及血清甘油三酯均下降(P<0.05);但HP/CVVH治疗组患者APACHEⅡ评分、炎性介质及甘油三酯水平在相同时间点明显低于CVVH组(P<0.05)。结论:HP/CVVH比CVVH能更有效地清除甘油三酯及炎性介质,提高生存率,有望成为SAP重要的辅助治疗措施。
Objective: To explore the therapeutic effect of different blood purification methods on hyperlipidemic pancreatitis. METHODS: Twenty-eight patients with hyperlipidemic pancreatitis between January 2016 and June 2017 were selected. Among them, 15 patients underwent hemoperfusion combined with hemofiltration (HP / CVVH) and 13 patients underwent hemofiltration (CVVH group). Vital signs, APACHEⅡscore, changes of plasma inflammatory mediators (TNF-α, IL-6 and IL-8) and serum triglyceride were compared between the two groups before and after treatment. Results: After treatment, the clinical symptoms, APACHEⅡscore, plasma inflammatory mediators and serum triglycerides were decreased in both groups (P <0.05). However, the APACHEⅡscore, inflammatory mediators and triglycerides in HP / CVVH group were The same time point was significantly lower than the CVVH group (P <0.05). Conclusion: HP / CVVH can clear triglycerides and inflammatory mediators more effectively than CVVH and improve survival rate, which is expected to become an important adjuvant therapy for SAP.