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目的：探讨产前对孕产妇四项感染性病原体血清标志物的检测及临床意义。方法本院2013年7月～2014年6月就诊的孕产妇5586例，分别在产前进行乙肝两对半、丙肝抗体(抗-HCV)、艾滋病病毒1/2抗体(抗-HIVl/2)、梅毒螺旋体抗体（抗-TP）。结果5586例孕产妇中，HBsAg阳性者648例(11.60%)，丙肝抗体阳性者9例(0.16%)，艾滋病病毒1/2抗体初筛阳性者1例(0.02%)，梅毒螺旋体抗体(TPPA)阳性者50例(0.90%)，其中T R U S T阳性者18例(0.32%)。结论对孕产妇进行产前血清标志物的检测，能够及时发现潜在的传染源，预防和控制母婴垂直传播，对避免医务人员职业暴露、医院感染及医疗纠纷的发生具有重要的意义。“,”Objective Investigate the correlation between the prenatal maternal four infectious pathogen detection and clinical significance of serum marker. Methods Our col ege in July 2013 to June 2013 of 5586 cases of pregnant and parturient women, respectively the second liver two half-and-half in prenatal, hepatitis c antibody (anti - HCV), HIV 1/2 antibody (anti - HIVl / 2), treponema pal idum antibody (anti - TP). Results Of 5586 cases of maternal, HBsAg positive for 648 cases (11.60%), and hepatitis c antibody was 9 cases (0.16%), at the beginning of the HIV 1/2 antibody screening positive for 1 case (0.02%), treponema pal idum antibody (TPPA) was 50 cases (0.90%), the TRUST was 18 cases (0.32%). Conclusions For prenatal maternal serum marker detection, to discover the potential source of infection, prevention and control of mother-to-child vertical transmission, to avoid medical staff occupational exposure, hospital infection and the occurrence of medical disputes has the vital significance.