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目的探讨妊娠期肝内胆汁淤积症(ICP)对胎儿的影响。方法选择孕足月ICP产妇40例为观察组(ICP组),正常孕足月产妇40例为对照组,分娩后测定脐静脉血清胆汁酸(TBA)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、肿瘤坏死因子-α(TNF-α)。结果 ICP组脐静脉血清胆汁酸(TBA)、ALT、AST、TNF-α均明显高于正常组,差异有统计学意义(P<0.05)。结论 ICP能造成胎儿肝功能异常,能导致胎儿有害细胞因子增加。
Objective To investigate the effect of intrahepatic cholestasis of pregnancy (ICP) on the fetus. Methods Forty pregnant women with ICP at full pregnancy were selected as the observation group (ICP group). Forty pregnant women with normal gestational age were selected as the control group. Serum bile acid (TBA), alanine aminotransferase (ALT) Aspartate aminotransferase (AST), tumor necrosis factor-alpha (TNF-alpha). Results The serum bile acid (TBA), ALT, AST and TNF-α in umbilical vein of ICP group were significantly higher than those of normal group (P <0.05). Conclusion ICP can cause fetal liver dysfunction, can lead to increased fetal cytokines.