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目的:探讨4.1B蛋白表达与非小细胞肺癌(NSCLC)进展的关系。方法:收集166例临床手术切除、石蜡包埋的原发NSCLC组织,免疫组化检测4.1B蛋白表达,分析其与NSCLC进展的关系。结果:26例4.1B蛋白表达于细胞膜上,69例4.1B蛋白表达缺失,71例胞浆表达。包括胞浆表达在内,4.1B蛋白异常表达率为84.34%。肿瘤最大直径≤3cm组、未转移组、临床分期Ⅰ和Ⅱ期组4.1B蛋白胞膜表达阳性率分别高于肿瘤最大直径>3cm组、转移组、Ⅲ和Ⅳ期组,差异有统计学意义(P<0.0.1),但4.1B细胞浆表达阳性率在各组间差异无统计学意义(P>0.05)。结论:在NSCLC组织内,4.1B蛋白存在表达缺失现象,也存在异常定位现象。表达于细胞膜的4.1B蛋白在NSCLC发展过程中可能发挥抑制作用,其表达缺失可能促进肿瘤进展。
Objective: To investigate the relationship between 4.1B protein expression and the progression of non-small cell lung cancer (NSCLC). Methods: A total of 166 clinically resected and paraffin-embedded primary NSCLC tissues were collected. The expression of 4.1B protein was detected by immunohistochemistry and the relationship with the progression of NSCLC was analyzed. RESULTS: Twenty-six cases of 4.1B protein were expressed on the cell membrane. The expression of 4.1B protein was absent in 69 cases, and 71 cases were cytoplasm. Including the expression of cytoplasm, the aberrant expression of 4.1B protein was 84.34%. The positive expression rates of 4.1B protein in tumor group with maximum diameter ≤3cm, non-metastasis group and clinical stageⅠandⅡgroup were higher than those with> 3cm in maximum diameter, metastasis group, Ⅲ and Ⅳ, respectively (P <0.0.1), but the positive rate of 4.1B cytoplasm was no significant difference among the groups (P> 0.05). Conclusion: The expression of 4.1B protein is absent in NSCLC tissues, and abnormal localization phenomenon exists. 4.1B protein expressed in the cell membrane may play an inhibitory role in the development of NSCLC, and its lack of expression may promote tumor progression.