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目的探讨新疆维汉民族高尿酸血症患者尿酸水平与代谢综合征的关系。方法选取维吾尔族和汉族高尿酸血症患者1 032例,测量人体基本参数,检测血尿酸(SUA)和血脂等相关生化指标。结果 SUA、体重指数(BMI)、甘油三酯(TG)、总胆固醇(TC)及低密度脂蛋白胆固醇(LDL-C)在维、汉民族间差异有统计学意义(P<0.01),SUA与高密度脂蛋白胆固醇(HDL-C)呈负相关,与其他生化指标均呈正相关(P<0.01)。维汉两民族代谢综合征的检出率差异无统计学意义(P>0.05),而超重或肥胖、高血糖的检出率差异有统计学意义(P<0.05)。SUA四分位数Ⅲ水平人群比Ⅰ水平人群患代谢综合征的风险高(OR=1.48,95%CI:1.01~2.18)。结论 SUA水平与代谢综合征各组分相关,SUA水平是代谢综合征的危险因素。
Objective To investigate the relationship between uric acid level and metabolic syndrome in patients with hyperuricemia in Xinjiang Uighur ethnic group. Methods A total of 1032 Uygur and Han patients with hyperuricemia were enrolled in this study. The basic parameters of the human body were measured, and the biochemical parameters such as serum uric acid (SUA) and serum lipids were measured. Results The SUA, BMI, TG, TC and LDL-C in Victoria and Han were significantly different (P <0.01). SUA Negatively correlated with high-density lipoprotein cholesterol (HDL-C), and with other biochemical indicators (P <0.01). There was no significant difference in the detection rate of metabolic syndrome between the two ethnic groups in Uyghur and Han (P> 0.05), while the detection rate of overweight or obesity and hyperglycemia was significantly different (P <0.05). Patients with SUA quartile III had a higher risk of having metabolic syndrome than those with level I (OR = 1.48, 95% CI: 1.01-2.18). Conclusions The level of SUA is related to the components of metabolic syndrome. SUA level is a risk factor of metabolic syndrome.