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目的探讨小儿重症肺炎并发心肌损害中心肌钙蛋白I(cardiac troponinⅠ,cTnⅠ)的测定及其意义。方法选取重症肺炎患儿200例为观察组,轻症肺炎患儿180例为轻症组,正常儿童200例为对照组,对比3组儿童cTnⅠ水平、肌酸激酶同工酶(creatine kinase MB,CK-MB)水平。结果观察组cTnI、CK-MB、肌酸激酶(creatine kinase,CK)、乳酸脱氢酶(lactate dehydrogenase,LDH)及天冬氨酸转氨酶(aspartate amino-transferase,AST)水平高于轻症组(P<0.05),观察组和轻症组cTnI、CK-MB、LDH、AST水平高于对照组(P<0.05)。观察组cTnI阳性率高于轻症组(P<0.05)。观察组与轻症组CK-MB阳性率差异无统计学意义(P>0.05)。结论重症肺炎患儿多伴有不同程度的心肌损害,cTnI可作为监测心肌损伤的重要标志物。早期检测cTnI有利于重症肺炎并发心急损害患儿的早期诊疗,从而预防心肌衰竭发生。
Objective To investigate the determination of cardiac troponin I (cTnⅠ) in children with severe pneumonia complicated with myocardial damage and its significance. Methods 200 children with severe pneumonia were selected as the observation group. 180 children with mild pneumonia were selected as the mild group and 200 normal children as the control group. The levels of cTnⅠ, creatine kinase MB CK-MB) levels. Results The levels of cTnI, CK-MB, creatine kinase (CK), lactate dehydrogenase (LDH) and aspartate amino-transferase (AST) in the observation group were significantly higher than those in the mild group P <0.05). The levels of cTnI, CK-MB, LDH and AST in observation group and mild disease group were higher than those in control group (P <0.05). The positive rate of cTnI in observation group was higher than that in mild group (P <0.05). The positive rate of CK-MB in observation group and mild group had no significant difference (P> 0.05). Conclusions Children with severe pneumonia are often accompanied by different degrees of myocardial damage, cTnI can be used as an important marker for monitoring myocardial injury. Early detection of cTnI is conducive to early diagnosis and treatment of children with severe pneumonia and acute myocardial infarction, thereby preventing myocardial failure.