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目的：探讨红细胞免疫功能及自然杀伤（ＮＫ）细胞活性在子宫内膜异位症（内异症）发病中的作用，以及两者之间的相关性。方法：采用红细胞Ｃ３ｂ受体花环试验（ＲＣ３ｂＲ）及红细胞免疫复合物花环试验（ＲＩｃＲ）测定４４例内异症患者（内异症组）红细胞免疫功能变化，采用４－甲基偶氮唑盐（ＭＴＴ）法检测患者外周血ＮＫ细胞活性，并与正常妇女（对照组）进行比较。结果：内异症组ＲＣ３ｂＲ及ＮＫ细胞活性低于对照组（Ｐ＜０．０５），其值随内异症病情加重有逐渐下降趋势；内异症组Ⅲ，Ⅳ期患者ＲＩｃＲ较对照组明显升高（Ｐ＜０．０５）。４４例内异症患者ＲＣ３ｂＲ值与ＮＫ细胞活性的降低程度呈直线正相关（ｒ＝０．６６５９，Ｐ＜０．０１）。结论：内异症患者红细胞免疫功能及ＮＫ细胞活性的降低可能与该病的发生与发展有关。
Objective: To investigate the role of erythrocyte immune function and natural killer (NK) cell activity in the pathogenesis of endometriosis (endometriosis) and their relationship. Methods: The changes of erythrocyte immune function in 44 patients with endometriosis (endometriosis group) were measured by the red blood cell C3b receptor rosette test (RC3bR) and the red blood cell immune complex rosette test (RIcR) MTT assay was used to detect NK cell activity in peripheral blood of patients and compared with normal women (control group). Results: The activity of RC3bR and NK cells in endometriosis group was lower than that in control group (P <0.05). The value of RC3bR and NK cell decreased gradually with the severity of endometriosis. The RIcR in stage Ⅲ and Ⅳ endometriosis group was significantly higher than that in control group Increased (P <0.05). There was a linear positive correlation between RC3bR value and NK cell activity in 44 patients with endometriosis (r = 0.6659, P <0.01). Conclusion: Erythrocyte immune function and NK cell activity in patients with endometriosis may be related to the occurrence and development of the disease.