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目的探讨甲胎蛋白异质体(AFP-L3)检测在肝癌鉴别诊断中的意义。方法应用微量离心柱法分离检测小扁豆凝集素结合型AFP-L3的百分含量(AFP-L3%),同时检测血清中AFP总含量。结果以AFP-L3%>10%作为阳性判断标准,47例肝癌患者血清AFP-L3阳性率为72.3%,肝硬化和慢性肝炎AFP-L3%分别为0和1.8%,肝癌AFP-L3%水平明显高于肝硬化和慢性肝炎(P<0.01);以AFP>20μg/L作为阳性判断标准,肝癌、肝硬化和慢性肝炎患者血清中AFP阳性率分别为85.1%、35.7%和37.8%;以AFP、AFP-L3%作为诊断肝癌指标的灵敏度分别是85.1%、72.3%,特异度分别是55.4%、97.2%。结论AFP-L3%是肝癌鉴别诊断的有用指标。
Objective To investigate the significance of detecting AFP-L3 in the differential diagnosis of liver cancer. Methods The content of AFP-L3 in lentiform lectin-bound AFP-L3 was detected by micro-centrifugation and the total AFP content in serum was detected. Results The positive rate of AFP-L3 in serum of 47 patients with hepatocellular carcinoma was 72.3%, AFP-L3% of cirrhosis and chronic hepatitis were 0 and 1.8%, AFP-L3% of hepatocellular carcinoma (P <0.01). The positive rate of AFP in serum of patients with hepatocellular carcinoma, cirrhosis and chronic hepatitis was 85.1%, 35.7% and 37.8% with AFP> 20μg / L as the positive standard. The sensitivity of AFP and AFP-L3% were 85.1% and 72.3% respectively, and the specificity was 55.4% and 97.2% respectively. Conclusion AFP-L3% is a useful indicator of differential diagnosis of liver cancer.