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目的探讨阿托伐他汀抗动脉粥样硬化的作用。方法将29只新西兰白兔随机分为正常组7例、病理组7例、用药5周组7例及用药9周组8例。实验前后抽血测定血脂全套,主动脉标本用作普通光镜、透射电镜及斑块面积检查。结果阿托伐他汀显著降低胆固醇(TC)、甘油三酯(TG)及低密度脂蛋白胆固醇(LDL-C),升高高密度脂蛋白胆固醇(HDL-C),组织病理学检查显示用药组血管内膜厚度、内膜中泡沫细胞、平滑肌细胞(SMC)明显减少,未见合成型SMC,用药9周组与病理组相比斑块面积减小。结论阿托伐他汀具有明显的抗动脉粥样硬化的作用。
Objective To investigate the effect of atorvastatin on atherosclerosis. Methods Twenty-nine New Zealand white rabbits were randomly divided into normal group (n = 7), pathological group (n = 7), medication group (5 weeks) and medication group (n = 8). Blood test before and after blood test for a full set of blood, aortic specimens for ordinary light microscopy, transmission electron microscopy and plaque area check. Results Atorvastatin significantly reduced the levels of cholesterol, triglyceride and low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C). Histopathological examination showed that atorvastatin Intimal thickness, intimal foam cells, smooth muscle cells (SMC) decreased significantly, no synthetic SMC, 9-week treatment group compared with the pathological group reduced plaque area. Conclusion Atorvastatin has obvious anti-atherosclerosis effect.