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抗矽—14号[4—(7氯化喹啉基—4哌哔嗪—1)丙烷磷酸盐(简称磷酸喹哌)]。自1973年国内进行动物筛选发现抗矽—14号对实验性矽肺具有治疗效果后,国内有关科研单位相继进行了大量实验研究工作和初步临床观察。通过第三次抗矽—14全国协作会议,进一步肯定了动物实验效果和临床疗效。并发现部分病例X线胸片有好转趋势,已显示出对矽肺病具有一定的疗效和可喜苗头。我们从1974年8月起,分批采用抗矽—14号对单纯矽肺患者进行治疗,现将连续试用2—2.5年的11例患者治疗观察情况总结如下:
Silicon anti-Si-14 [4- (7 quinolyl-4-piperazepine-1) propane phosphate (referred to as Quipiper phosphate)]. Since 1973, domestic animal screening found anti-silicon -14 on the experimental silicosis has a therapeutic effect, the domestic scientific research units have carried out a large number of experimental studies and preliminary clinical observations. Through the third anti-silicon -14 national collaborative meeting, further confirmed the animal experimental results and clinical efficacy. And found that some cases of X-ray showed a trend of improvement, has shown a certain effect on silicosis and gratifying signs. From August 1974 onwards, we treated patients with silicosis alone in batches against Sil-14. We now summarize the treatment observations of 11 patients who have been continuously tested for 2 to 2.5 years: