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目的探讨不同生物亚群解脲脲原体(Uu)与不孕症的相关性。方法采用PCR方法对120例门诊不孕症患者(不孕症组)的宫颈分泌物进行Uu生物亚群分型检测;以同期健康体检中心120例正常体检女性为对照组。比较不同亚群Uu在不孕症组和对照组感染率的差异。结果不孕症组Uu检出率为55.0%(66/120),对照组为30.0%(36/120),两组比较,差异有统计学意义(χ~2=15.35,P<0.05);不孕症组Uu生物1群检出率为20.8%(25/120),对照组为18.3%(21/120),两组比较,差异无统计学意义(χ~2=0.24,P>0.05);不孕症组Uu生物2群检出率为45.8%(55/120),对照组为21.7%(26/120),两组比较,差异有统计学意义(χ~2=15.67,P<0.01)。结论 Uu感染与女性不孕有一定的相关性,Uu1群可能为正常携带,Uu2群可能为致病群,其潜在治病机制有待进一步研究。
Objective To investigate the relationship between different biological subgroups of Uu and infertility. Methods 120 cases of outpatients with infertility (infertility group) cervical secretions Uu biological subtype detection; 120 healthy women in the same period as the control group. Compare the different subpopulation Uu infertility group and control group differences in infection rates. Results The detection rate of Uu was 55.0% (66/120) in infertility group and 30.0% (36/120) in control group. The difference was statistically significant (χ ~ 2 = 15.35, P <0.05). The detection rate of Uu in 1 group was 20.8% (25/120) in infertility group and 18.3% (21/120) in control group, there was no significant difference between the two groups (χ ~ 2 = 0.24, P> 0.05 ). The detection rate of Uu in two groups was 45.8% (55/120) in infertility group and 21.7% (26/120) in control group, the difference was statistically significant (χ ~ 2 = 15.67, P <0.01). Conclusions There is a certain correlation between Uu infection and female infertility. The Uu1 group may be normal and the Uu2 group may be the causative group. The potential therapeutic mechanism remains to be further studied.