论文部分内容阅读
近年来糖尿病患者的数量急剧上升,其发生心血管疾病的概率是非糖尿病患者的2～3倍,其中内皮功能障碍被认为是糖尿病患者发生动脉粥样硬化(AS)血栓形成并发症的关键因素之一。内皮微颗粒是内皮细胞激活或损伤时产生的膜性小囊泡,具有促进粘附、扩大炎症反应和诱导新生血管增生等作用。近来的研究发现内皮微颗粒的水平在糖尿病患者中升高,在糖尿病合并肾血管病变或急性冠脉综合征时尤为显著。此外,对内皮微颗粒的表型研究提示糖尿病患者内皮损伤的机制可能与凋亡有关。内皮微颗粒的发现为研究糖尿病的发病机制开辟了新的研究平台,有望成为研究糖尿病的新的热点。
In recent years, the number of diabetics has risen sharply, with a 2 to 3 times greater risk of developing cardiovascular disease than nondiabetics, with endothelial dysfunction being considered as a key factor in the development of atherothrombotic (AS) thrombotic complications in diabetic patients one. Endothelial micro-particles are small vesicles produced by endothelial cell activation or injury, which can promote the adhesion, enlarge the inflammatory reaction and induce neovascularization. Recent studies have found that the level of endothelial microparticles in diabetic patients increased, especially in diabetic patients with renal vascular disease or acute coronary syndrome. In addition, phenotypic studies of endothelial micro-particles suggest that the mechanism of endothelial damage in diabetic patients may be related to apoptosis. The discovery of endothelial micro-particles has opened up a new research platform for studying the pathogenesis of diabetes and is expected to become a new hot spot in the study of diabetes.