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目的探讨左氧氟沙星不良反应(adverse reaction,ADR)的临床特点。方法总结分析2008年1月—2010年4月我院门诊及住院患者中出现左氧氟沙星ADR的92例患者的相关因素、临床表现类型以及治疗和预后。结果本组年龄<60岁患者有35例(38.04%),年龄≥60岁患者有57例(61.96%);静脉用药发生患者83例(90.22%),口服用药者9例(9.78%);联合用药所致70例(76.09%),单独用药22例(23.91%)。本组变态反应35例(38.04%),发生率位居首位;其次消化系统反应20例(21.74%),全身性损害15例(16.30%)等。所有患者经调整滴速、停药或对症处理后症状均消失。结论左氧氟沙星ADR发生率日趋升高,临床医护人员应掌握其相关因素,合理用药。
Objective To investigate the clinical characteristics of adverse reaction (ADR) of levofloxacin. Methods From January 2008 to April 2010, 92 patients with levofloxacin ADR in outpatients and inpatients from January 2008 to April 2010 were analyzed retrospectively. The related factors, clinical manifestations, treatment and prognosis were analyzed. Results 35 (38.04%) patients aged 60 or older, 57 (61.96%) patients aged 60 or older, 83 (90.22%) patients receiving intravenous drug and 9 patients (9.78% 70 cases (76.09%) caused by combination therapy and 22 cases (23.91%) treated alone. The group of allergic reactions in 35 cases (38.04%), the highest incidence rate; followed by digestive system reaction in 20 cases (21.74%), systemic injury in 15 cases (16.30%) and so on. All patients adjusted drip rate, withdrawal or symptomatic treatment after the symptoms disappeared. Conclusion The incidence of ADR in levofloxacin is increasing day by day. Clinicians should master the related factors and use them rationally.