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目的:探索急性脑出血患者的炎性因子和C-反应蛋白(CRP)的变化,以及这些炎性因子和CRP与患者疾病的预后和神经功能恢复状况的关系。方法:随机选取2015-03-2016-03在我院就诊的急性脑出血患者86例为观察组,86例健康志愿者作为对照组,在入院后1、3、7d取所有入选者空腹状态下的静脉血并检测IL-1β、IL-6、肿瘤坏死因子-α(TNF-α)、CRP含量,并在入院后1、3、7d对观察组进行日常生活活动能力量表(ADL)评分、格拉斯哥预后(GOS)评分、美国国立卫生研究院卒中量表(NIHSS)评分,并分析炎性因子和CRP与ADL评分、GOS评分、NIHSS评分的相关性。结果:观察组的IL-1β、IL-6、TNF-α、CRP浓度在患者急性脑出血后急性期即入院后1、3、7d均显著高于对照组;且观察组自入院后炎性因子IL-1β、IL-6、TNF-α及CRP浓度均呈下降趋势;入院后1、3、7d即急性期的IL-1β、IL-6、TNF-α、CRP浓度与ADL评分、GOS评分呈负相关关系,与NIHSS评分呈正相关关系。结论:脑出血患者急性期的炎性因子和CRP参与患者神经功能恢复的病理生理过程,可以用于评估患者的预后和神经功能恢复情况。
Objective: To explore the changes of inflammatory factors and C-reactive protein (CRP) in patients with acute cerebral hemorrhage and the relationship between these inflammatory factors and CRP and the prognosis of patients with disease and the recovery of neurological function. METHODS: Totally 86 patients with acute cerebral hemorrhage treated in our hospital from March 2015 to March 2016 were selected as the observation group and 86 healthy volunteers as the control group. All the patients were enrolled in the fasting state at 1, 3 and 7 days after admission The levels of IL-1β, IL-6, TNF-α and CRP were measured in the venous blood of the observation group and ADL scores of the observation group at 1, 3 and 7 days after admission , Glasgow Outcomes (GOS) scores, National Institutes of Health Stroke Scale (NIHSS) scores, and the association of inflammatory factors and CRP with ADL scores, GOS scores, and NIHSS scores. Results: The concentrations of IL-1β, IL-6, TNF-α and CRP in the observation group were significantly higher than those in the control group at the acute stage after acute cerebral hemorrhage (ie, at 1, 3 and 7 days after admission) The levels of IL-1β, IL-6, TNF-α and CRP in the acute phase decreased at 1, 3, 7 days after admission. The levels of IL-1β, IL-6, TNF- The score was negatively correlated with the NIHSS score. Conclusion: The acute phase of cerebral hemorrhage in inflammatory cytokines and CRP involved in the recovery of neurological function in patients with pathophysiological process can be used to assess the prognosis and recovery of patients with neurological function.