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目的 评价盐酸仑氨西林片和阿莫西林胶囊治疗呼吸道及皮肤软组织感染的安全性和有效性。方法 用双盲双模拟随机对照方法,治疗急性上呼吸道感染、皮肤软组织感染。剂量均为0.5g,tid,疗程7～14天。结果 共入选合格病例141例,其中仑氨西林组73例,痊愈率和有效率分别为71.2%和91.8%;对照组阿莫西林胶囊组68例,痊愈率和有效率分别为70.6%和94.1%;药物不良反应发生率仑氨西林组为6.9%,阿莫西林胶囊组为7.4%,2组临床疗效和药物不良反应均无统计学差异。结论 盐酸仑氨西林和阿莫西林是治疗常见急性细菌性呼吸道感染及皮肤软组织感染的较为安全、有效的抗菌药物。
Objective To evaluate the safety and efficacy of amoxicillin hydrochloride tablets and amoxicillin capsules in the treatment of respiratory and skin and soft tissue infections. Methods A double-blind double-dummy randomized controlled trial was used to treat acute upper respiratory tract infection and skin and soft tissue infections. The dosage is 0.5g, tid, treatment 7 to 14 days. Results A total of 141 eligible cases were enrolled. Of them, 73 cases were treated with amilcillin, the cure rate and effective rate were 71.2% and 91.8% respectively. In the control group, 68 cases were treated with amoxicillin capsules, the cure rate and effective rate were 70.6% and 94.1 %. The incidence of adverse drug reactions was 6.9% in the group receiving amoxicillin and 7.4% in the amoxicillin capsule group. There was no significant difference in clinical efficacy and adverse drug reactions between the two groups. Conclusion Lun ammonia amoxicillin and amoxicillin are safe and effective antimicrobial agents for the treatment of common acute bacterial respiratory infections and skin and soft tissue infections.