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万古霉素对革兰氏阳性球菌(除肠球菌外)、梭状芽胞杆菌属、类白喉杆菌、李司忒菌、放线菌,偶而对革兰氏阴性球菌均具杀菌作用,其精制品的分子量为1,448;本品象瑞斯托霉素(restocetin)一样,其活性部分是一配基。万古霉素紧密地与肽糖的D丙氨酸—D丙氨酸末端相联接,从而阻止细菌细胞壁肽糖的进一步合成。本品易与细菌结合,每个葡萄球菌可结合10~7万古霉素分子,而只能结合10~3青霉素G分子。由于本品不能诱
Vancomycin against Gram-positive cocci (except Enterococcus), Clostridium, diphtheria-like bacteria, Li Liste bacteria, actinomycetes, and occasionally Gram-negative bacteria have a bactericidal effect, the refined products The molecular weight of 1,448; This product is the same as restocetin (restocetin), the active part is a ligand. Vancomycin is tightly linked to the D-Alanine-D-Alanine terminus of peptidoglycan, thereby preventing further synthesis of bacterial cell wall peptidoglycan. This product is easy to combine with bacteria, each staphylococci can be combined with 10 to 7 vancomycin molecules, but only with 10 to 3 penicillin G molecules. Because this product can not be induced