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[目的]探讨乳腺癌组织中乳腺癌易患基因1(BRAC1)、DIAPH‐3蛋白的表达及其意义.[方法]采用免疫组化染色技术对本院病理科收集的92例乳腺癌组织(观察组) 、46例癌旁组织标本(对照组) .对比两组标本中的DIAPH‐3蛋白、BRAC1蛋白阳性表达率,并分析不同TNM分期、淋巴结转移、肿瘤病灶直径、脉管浸润程度、组织学分级患者中的DIAPH‐3蛋白、BRAC1蛋白表达程度.[结果]乳腺癌组中的DIAPH‐3蛋白、BRAC1蛋白阳性表达率分别为45 .65%(42／92) 、67 .39%(62／92) ,癌旁组则分别为84 .78%(39／46) 、15.22%(7／46) ,两组比较差异具有统计学意义( P ＜0 .05).不同TNM分期、是否淋巴结转移的乳腺癌组中的DIAPH‐3蛋白阳性表达率组间比较,差异具有统计学意义( P ＜0 .05) .不同 TNM 分期、是否淋巴结转移、不同肿瘤分化程度的乳腺癌组中的BRAC1蛋白阳性表达率组间比较差异具有统计学意义( P ＜0 .05) .[结论]乳腺癌组织中的DIAPH‐3蛋白表达下调、BRAC1蛋白表达上调,并且与肿瘤的发生、发展关系密切.“,”To investigate the expression and significance of breast cancer susceptibility gene 1 (BRAC1) and DIAPH‐3 protein in breast cancer .[M ethods]Immunohistochemical staining was used to detect 92 cases of breast cancer (observation group) and 46 cases of paracancerous tissue specimens (control group). T he positive expression rates of DIAPH‐3 protein and BRAC1 protein in two groups were compared ,and the expression levels of DIAPH‐3 protein and BRAC1 protein in patients with different T NM stages ,lymph node metastasis ,tumor lesion diameter ,vascular invasion ,histological grade were analyzed .[Results]T he positive rates of DIAPH‐3 protein and BRAC1 protein in the breast cancer group were 45 .65%(42／92 ) and 67 .39%(62／92) ,respectively ,while those in the paracancerous group were 84 .78%(39／46) and 15 .22%(7／46) ,re‐spectively .T here was a significant difference between the two groups ( P ＜ 0 .05 ).T he positive expression rates of DIAPH‐3 protein in breast cancer patients with different T NM stages and lymph node metastasis were significantly different ( P ＜ 0 .05 ).T he positive expression rate of BRAC 1 protein in breast cancer patients with different T NM stages ,lymph node metastasis and tumor differentiation was significantly different ( P ＜0 .05).[Conclusion]T he down‐regulation of DIAPH‐3 and up‐regulation of BRAC1 in breast cancer are closely related to the occurrence and development of tumor .