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为了解原癌基因对胎盘滋养层细胞的影响，用原癌基因ｃ－ｆｏｓ、ｐ５３蛋白的抗体和运动神经诱向因子１（ｍｏｔｏｎｅｕｒｏｎｏｔｒｏｐｈｉｃｆａｃｔｏｒ１，ＭＮＴＦ１）抗独特型抗体的免疫组织化学技术，研究了ｃ－ｆｏｓ、ｐ５３及ＭＮＴＦ１受体在人早期胎盘的分布。人早期胎盘的两类滋养层细胞及绒毛中轴的基质细胞均呈ｃ－ｆｏｓ、ｐ５３免疫反应性，反应产物大部分布于胞核内。在相邻切片上，ｃ－ｆｏｓ免疫反应性细胞同样显示ＭＮＴＦ１受体免疫反应性，其反应物质分布于胞质内。以上结果提示，原癌基因ｃ－ｆｏｓ和ｐ５３可能参与调控绒毛细胞的增殖分化，而且ｃ－ｆｏｓ和ＭＮＴＦ１受体可能有协同调控作用。
To understand the effect of protooncogenes on placental trophoblast cells, immunohistochemistry with anti-idiotypic antibodies against proto-oncogene c-fos, p53 and motoneuronotrophic factor 1 (MNTF1) Distribution of -fos, p53 and MNTF1 receptors in early human placenta. Human early placenta of two types of trophoblast cells and villous axis of stromal cells were c-fos, p53 immunoreactivity, most of the reaction products in the nucleus. On adjacent sections, c-fos immunoreactive cells also showed MNTF1 receptor immunoreactivity with reactive material distributed in the cytoplasm. These results suggest that proto-oncogene c-fos and p53 may be involved in the regulation of villus proliferation and differentiation, and c-fos and MNTF1 receptors may have a synergistic regulatory role.