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目的对老年晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者进行中药汤剂口服联合氩氦刀冷冻治疗的生存影响进行临床观察分析。方法采用前瞻性研究方法,共观察90例老年晚期NSCLC患者氩氦刀冷冻前后生活质量的变化、局部瘤灶的复发转移情况及生存期并进行统计分析。结果治疗组、对照组的中位生存期分别为14个月、11个月。根据Karnofsky功能状态评分标准及生活质量评分标准(QOL),在患者术前和术后3个月、6个月生活质量变化,局部瘤灶转移率,氩氦刀术后中位生存期及1年、18个月的生存率方面,P<0.05,治疗组优于对照组。结论中药联合氩氦刀的“绿色治疗”模式对44例老年晚期NSCLC患者的生存影响方面具有明显意义。
Objective To investigate the clinical effects of oral decoction combined with cryoablation in elderly patients with advanced non-small cell lung cancer (NSCLC). Methods A prospective study was conducted to observe the changes of the quality of life before and after cryoablation of 90 patients with advanced NSCLC, the recurrence and metastasis of local tumor, and the statistical analysis. Results The median survival of treatment group and control group were 14 months and 11 months respectively. According to Karnofsky functional status score and quality of life score (QOL), the patients’ preoperative and postoperative 3 months, 6 months quality of life changes, local tumor metastasis rate, the median survival time after cryoablation and 1 Year, 18-month survival rate, P <0.05, the treatment group was better than the control group. Conclusion The “green treatment” mode of traditional Chinese medicine combined with cryoablation has significant effect on the survival of 44 elderly patients with advanced non-small cell lung cancer.