Parkinsons disease (PD), the second most common neurodegenerative disorder in the elderly, is characterized by the degeneration of melanized dopamine contai
Inflammation is a key part of central nervous system pathophysiology.Recently, it is thought that inflammatory factors may have both beneficial and deleteri
The motor deficits associated with Parkinson s disease (PD) appear due in large part to the loss of dopamine (DA)-containing neurons projecting from substan
Circulating endothelial progenitor cells (EPCs) has been linked to the risk factor and prognosis of cerebrovascular or cardiovascular diseases.However, the
Mammalian Sirtl, the closest homolog of yeast sir2, is a NAD+ dependent protein deacetylase.Liver specific deletion of Sirtl abolished AKT activation upon i
Aging increases predisposition to critical illness and old age is an independent risk factor for mortality in critically ill patients.Mitochondrial function