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印度尼西亚的西加里曼丹于1987年、1989年和1991年爆发了三次肝炎大流行。从第一次肝炎流行时病人排泄的粪便中曾经检出了戊型肝炎病毒(HEV)基因组,证实HEV是1987年肝炎大流行的致病因子。但是,对后两次肝炎大流行的病因学因素尚不清楚,为此作者进行了这次研究。 采集1991年肝炎流行时发病的89例急性肝炎患者的血清标本,用酶免疫试验(EIA)检测抗-HEV,以及HAV、HBV和HCV感染的血清学标志。另外,用盲法随机选取30价标本作Western印迹试验,检测血清中
West Kalimantan in Indonesia broke out three hepatitis pandemics in 1987, 1989 and 1991. The hepatitis E virus (HEV) genome was detected from the excretion of the patient during the first hepatitis epidemic and confirmed that HEV was a causative agent of the 1987 hepatitis epidemic. However, the etiological factors of the latter two hepatitis outbreaks are not yet known and the authors conducted this study. Serum samples from 89 patients with acute hepatitis at the onset of hepatitis B in 1991 were collected and serological markers of anti-HEV and HAV, HBV and HCV infection were tested by enzyme immunoassay (EIA). In addition, blind selection of 30 random samples for Western blot test, detection of serum