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[目的]探讨多药耐药基因相关蛋白在胃癌组织中的表达及其与预后的关系。[方法]免疫组化方法检测109例胃癌组织中ToPoⅡ、MRP、GST-π的表达,并分析他们与胃癌临床病理特征和预后间的关系。[结果]109例胃癌组织中,ToPoⅡ、MRP、GST-π阳性率分别为74.3%、40.4%和48.6%。3种蛋白各自表达的阳性组与阴性组比较,1、3、5年生存率均无统计学差异。高危组(2个以上危险因素)1、3、5年生存率分别为85.1%、57.4%、46.8%;低危组(1个危险因素)1、3、5年生存率分别为85.5%、64.5%、61.3%,但差异无统计学意义(χ2=0.15,P=0.926)。[结论]ToPoⅡ、MRP、GST-π与胃癌临床病理特征相关,3种耐药蛋白的联合检测可能成为预测胃癌患者预后的指标。
[Objective] To investigate the expression of multidrug resistance gene related protein in gastric carcinoma and its relationship with prognosis. [Method] The expressions of ToPoⅡ, MRP and GST-π in 109 cases of gastric cancer tissues were detected by immunohistochemistry and their relationship with clinicopathological features and prognosis of gastric cancer was analyzed. [Results] The positive rates of ToPoⅡ, MRP and GST-π in 109 cases of gastric cancer were 74.3%, 40.4% and 48.6% respectively. There was no significant difference in the 1,3 and 5-year survival rates between the positive group and the negative group of the three proteins. The 1, 3, 5-year survival rates were 85.1%, 57.4% and 46.8% respectively in the high-risk group (1 risk factor) and 1, 3 and 5-year survival rates were 85.5% 64.5%, 61.3%, but the difference was not statistically significant (χ2 = 0.15, P = 0.926). [Conclusion] ToPoⅡ, MRP and GST-π are correlated with the clinicopathological features of gastric cancer. The combined detection of three kinds of resistance proteins may be an index to predict the prognosis of patients with gastric cancer.