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目的分析糖类抗原CA125、CA199和胚胎类肿瘤标志物癌胚抗原(CEA)单独及联合检测在卵巢癌诊断中的价值。方法空腹静脉采血,化学发光法分别检测40例健康体检组妇女、27例卵巢癌患者和42例卵巢良性疾病患者血清CA125、CA199及CEA水平。结果 37例卵巢癌患者空腹血清CA125、CA199及CEA值明显高于卵巢良性疾病患者及健康体检对照组,差异有统计学意义(P<0.01),血清CA125单项意义明显大于CA199和CEA;CEA和CA199水平在健康体检组和卵巢良性疾病组比较差异无统计学意义(P>0.05)。三项联合检测的阳性率和准确性比单独检测明显提高,对临床诊断较有意义。结论 CA125、CA199及CEA联合检测对卵巢癌与卵巢良性疾病的诊断和鉴别诊断及疾病的转归有重要价值,值得临床推广应用。
Objective To analyze the value of carbohydrate antigen CA125, CA199 and embryonal tumor marker carcinoembryonic antigen (CEA) in the diagnosis of ovarian cancer. Methods Fasting venous blood and chemiluminescence were used to detect the levels of serum CA125, CA199 and CEA in 40 healthy women, 27 patients with ovarian cancer and 42 patients with benign ovarian disease. Results The fasting serum CA125, CA199 and CEA in 37 patients with ovarian cancer were significantly higher than those in patients with benign ovarian disease and healthy controls (P <0.01), and the single significance of serum CA125 was significantly greater than that of CA199 and CEA. CEA and CEA There was no significant difference in the level of CA199 between healthy group and benign ovarian disease group (P> 0.05). The positive rates and accuracy of the three combined tests were significantly higher than those of single tests, which made more sense for clinical diagnosis. Conclusion The combined detection of CA125, CA199 and CEA has important value in the diagnosis and differential diagnosis of ovarian cancer and ovarian benign disease and the prognosis of the disease, and is worthy of clinical application.