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目的：探讨急性肾小球肾炎（ＡＧＮ）肾脏损伤与脂质过氧化反应的关系。方法：用硫代巴比妥酸比色法测定３０例ＡＧＮ患儿尿丙二醛（ＭＤＡ），并与同步测定的其他实验室指标进行对比。结果：ＡＧＮ急性期尿ＭＤＡ升高，恢复期降至正常水平。尿ＭＤＡ与血清ＭＤＡ、血沉呈显著正相关，与血清补体（Ｃ３）、超氧化物歧化酶（ＳＯＤ）呈显著负相关。结论：尿ＭＤＡ可作为判断ＡＧＮ病情活动性及其程度，评价近期转归的指标
Objective: To investigate the relationship between renal injury and lipid peroxidation in acute glomerulonephritis (AGN). Methods: Urinary malondialdehyde (MDA) in 30 patients with AGN was measured by thiobarbituric acid colorimetric method and compared with other laboratory parameters measured synchronously. Results: Urine MDA was increased in acute stage of AGN and returned to normal in convalescent stage. There was a significant positive correlation between urinary MDA and serum MDA and erythrocyte sedimentation rate, but negatively correlated with serum complement (C3) and superoxide dismutase (SOD). Conclusion: Urine MDA can be used as a measure of AGN activity and extent of disease, evaluation of the recent outcome of the index