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目的:观察泻黄散合导赤散治疗复发性口腔溃疡的临床效果。方法:将复发性口腔溃疡患者100例,随机分为对照组与治疗组,对照组给予维生素B2、维生素C、华素片及罗红霉素口服,治疗组给予泻黄散合导赤散治疗。比较2组的临床疗效、不良反应和复发情况。结果:痊愈率和总有效率治疗组分别为30.0%、96.0%,对照组分别为10.0%、80.0%,2组痊愈率、总有效率分别比较,差异均有显著性意义(P<0.05)。治疗组患者用药后未见明显不良反应,对照组4例患者服用罗红霉素后出现胃肠反应,药物减量及对症治疗后反应消失。治疗组4例患者复发,复发率8.33%,平均出现在停药后9月;对照组24例患者复发,复发率60.00%,平均在停药后4月左右。2组复发率比较,差异有显著性意义(P<0.05)。溃疡愈合时间治疗组平均(8.1±1.2)天,对照组平均(14.5±3.1)天,2组比较,差异有显著性意义(P<0.05)。结论:泻黄散合导赤散治疗复发性口腔溃疡安全且疗效显著,值得在临床上进一步推广和应用。
Objective: To observe the clinical effect of “Xie Huang San He Gu Chuan San” in the treatment of recurrent oral ulcer. Methods: One hundred patients with recurrent oral ulcer were randomly divided into control group and treatment group. The control group was treated with vitamin B2, vitamin C, Hua-Liao tablets and roxithromycin orally. The clinical efficacy, adverse reactions and recurrence in the two groups were compared. Results: The cure rate and total effective rate in the treatment group were 30.0% and 96.0%, respectively, while those in the control group were 10.0% and 80.0% respectively. There was significant difference between the two groups in cure rate and total effective rate (P <0.05) . The patients in the treatment group showed no obvious adverse reactions after treatment. The patients in the control group had gastrointestinal reactions after taking roxithromycin, and the reactions were disappeared after drug reduction and symptomatic treatment. In the treatment group, 4 patients relapsed with a recurrence rate of 8.33%, with an average of 9 months after discontinuation. In the control group, 24 patients relapsed and the recurrence rate was 60.00%, with an average of about 4 months after drug withdrawal. There was significant difference between the two groups (P <0.05). The ulcer healing time was (8.1 ± 1.2) days in the treatment group and 14.5 ± 3.1 days in the control group. There was significant difference between the two groups (P <0.05). Conclusion: It is safe and effective to treat recurrent oral ulcer with “Pulmonary Diarrhea and Chizhixian Powder”, which is worth further promotion and application in clinic.