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目的探讨单硝酸异山梨酯对实验性大鼠胃溃疡的影响。方法采用乙酸造成大鼠胃溃疡模型,50只SD大鼠随机分为5组,即正常对照组、模型组、兰索拉唑(5mg/kg)组、单硝酸异山梨酯高剂量(4mg/kg)组和低剂量(2mg/kg)组,成模3d后开始给药,连续给药14d后处死,然后观察各组大鼠溃疡指数、胃液pH值、病理组织HE染色切片和AB-PAS染色切片。结果与模型组比较,单硝酸异山梨酯高、低二剂量组和兰索拉唑组大鼠胃溃疡指数减低和HE染色显示胃黏膜修复的效果明显,低剂量单硝酸异山梨酯组AB-PAS阳性面积较模型组减少,与正常对照组无差别。结论单硝酸异山梨酯可促进实验性大鼠胃溃疡愈合。
Objective To investigate the effect of isosorbide mononitrate on gastric ulcer in rats. Methods Fifty SD rats were randomly divided into five groups: normal control group, model group, lansoprazole (5 mg / kg) group, high dose of isosorbide mononitrate (4 mg / kg) and low dose (2mg / kg). The rats were sacrificed after 3 days and were sacrificed 14 days after administration. The ulcer index, gastric juice pH value, pathological HE staining sections and AB-PAS Dyeing sections. Results Compared with model group, the indexes of gastric ulcer and HE staining in isosorbide mononitrate high and low dose groups and lansoprazole group were significantly lower than those in model group. The effect of gastric mucosal repair was obvious. In low dose isosorbide dinitrate group, AB- PAS positive area than the model group decreased, no difference with the normal control group. Conclusion Isosorbide mononitrate can promote the healing of experimental gastric ulcer in rats.