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本文作者等发现4-甲基-6-肼基嘧啶缩醛(4—methyl—6-hydrazinopyrimidine)对各称细菌具有一定的活性,但是较低(0.1—0.5 mg/ml.)。另外一些工作者用2-肼基缩醛-4,6-二甲基(2—hydrazino—4,6—dimethyl—)和2,4,二肼基嘧啶缩醛(2,4-dihydrazino pyrimidine)作试验,也获得了同样的结果。由此引导出制备了几种其它肼基嘧啶缩醛类的化合物,然面他们的活性都没有4-甲基肼6·肼基嘧啶缩醛的高。在研究这些物质时,发现缩合物之一,2-(肼缩水杨醛)4-甲基-6-羟基嘧啶对抑制结核菌有高的活性,研究的结果启示他们大量制备了含有这个基团的物质,这些物质的抗
The authors found that 4-methyl-6-hydrazinopyrimidine has some activity against all bacterial species, but lower (0.1-0.5 mg / ml.). Other workers used 2-hydrazino-4,6-dimethyl- and 2,4-dihydrazino pyrimidine For the experiment, the same result was obtained. This led to the preparation of several other hydrazinopyrimidal acetal compounds, however, none of their activity is high with 4-methylhydrazine 6-hydrazinopyrimidal. In the study of these substances, one of the condensates, 2- (hydrazinosalicylaldehyde) 4-methyl-6-hydroxypyrimidine, was found to have a high inhibitory activity against Mycobacterium tuberculosis, and the results of the study revealed that they prepared a large amount of The material, the resistance of these substances