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目的：观察亚甲蓝封闭联合苦参汤熏洗对治疗慢性肛门湿疹的临床疗效。方法：将84例慢性肛门湿疹患者随机分为两组，治疗组42例予以亚甲蓝封闭联合苦参汤熏洗治疗，对照组42例予以亚甲蓝封闭后用派瑞松外涂治疗。结果：治疗组患者的总有效率为97.62％，对照组总有效率78.57%，两组总有效率具有差异(P<0.05)。经过6个月随访，治疗组有3例复发患者，复发率复发率9.38%，对照组复发7例，复发率38.89%。结论：亚甲蓝封闭联合苦参汤熏洗治疗慢性肛门湿疹有着较好的治疗效果，治愈率高，不易复发。“,”Objective: To observe the clinical effect of methylene blue combined with Matrine Decoction on chronic anal eczema. Methods: 84 cases of chronic anal eczema were randomly divided into two groups. the observation group of 42 cases were treated with methylene blue blocking combined Kushen Decoction fumigation, the control group of 42 cases were treated with methylene blue after sealing with Pevisone coating. Results: the total effective rate of the treatment group was 97.62%, the control group was 78.57%, the total effective rate of the two groups had significant difference (P<0.05). At 6 months fol ow-up, the treatment group had 3 cases of recurrence, the recurrence rate was 9.38%. The control group had 7 cases of recurrence, the recurrence rate was 38.89%. Conclusion: the combination of methylene blue and matrine Decoction in the treatment of chronic anal eczema has a good curative effect, cure rate is high, and it is not easy to recur.