抗癌药物疗效预测的实验研究

• 作 者: 阎玉森 马永泉 李祥周 穆克春 周达生
• 机 构: 8l医院,8l医院,8l医院,8l医院,南京铁道医学院卫生系
• 出 处: 解放军医学杂志
• 发表日期: 1983年05期
• 关键词: 丝裂霉素 氟脲嘧啶 疗效预测 药物敏感试验 乳腺癌 氚标记 胸腺嘧啶核苷 抗癌药物 癌细胞 抑制程度

本文介绍化学抗癌药物敏感试验,包括动物实验和取材于手术的人体原代癌细胞,利用氚标记的胸腺嘧啶核苷参入细胞DNA原理,观察癌细胞受药物抑制程度。实验结果证明,丝裂霉素和氟脲嘧啶对胃癌、贲门癌病人作用最强,长春新硷及肿节风次之;对乳腺癌以活化后的环磷酰胺及氟脲嘧啶为佳,而丝裂霉素及氮芥次之;蟾酥对胃、贲门及乳腺癌均未见明显作用。

This article describes the chemical anticancer drug susceptibility test, including animal experiments and human primary cancer cells derived from surgery, the use of technetium-labeled thymidine incorporation into the cell DNA principle to observe the extent of cancer drug inhibition. The experimental results show that mitomycin and fluorouracil have the strongest effect on patients with gastric cancer and cardiac cancer, followed by Changchun Xinjing and Tuojiefeng. It is better to use activated cyclophosphamide and fluorouracil for breast cancer. The mitomycin and nitrogen mustard were the next best; the wolfberry had no significant effect on the stomach, fontanelle and breast cancer.