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目的:制备三七总皂苷脂质体微丸。方法:以包封率为考察指标,大豆磷脂-胆固醇、水相-有机相,药物质量浓度,脂类用量为考察因素,通过正交设计优选三七总皂苷脂质体冻干粉的处方工艺,采用塑制法制备三七总皂苷脂质体微丸。结果:三七总皂苷脂质体冻干粉的最佳处方工艺为大豆磷脂-胆固醇(6∶1),水相-有机相(1∶4),药物质量浓度20 g·L-1,磷脂用量150 mg。制备的脂质体微丸溶解后脂质体的平均粒径220.5 nm,Zeta电位-71.21 mV,1 h内溶出度达81.41%。结论:制备的三七总皂苷脂质体微丸体外溶出度较高,脂质体的粒径分布较好、质量稳定。
Objective: To prepare notoginsenoside liposomes pellets. Methods: Taking encapsulation efficiency as index, soybean phospholipid - cholesterol, aqueous phase - organic phase, drug concentration and lipid dosage as the investigation factors, the orthogonal design was adopted to optimize the prescription of Panax notoginseng total saponin liposome lyophilized powder Panax notoginseng liposomes were prepared by plastic method. Results: The best prescription of total saponin liposomes freeze-dried powder was soybean lecithin-cholesterol (6:1), aqueous-organic phase (1:4), drug concentration 20 g · L -1, phospholipid Amount 150 mg. The average diameter of liposomes was 220.5 nm and the Zeta potential was-71.21 mV. The dissolution rate reached 81.41% in 1 h. Conclusion: The Panax notoginseng saponin liposomes prepared in vitro have higher dissolution rate, better particle size distribution and stable quality.