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目的探讨乳果糖和庆大霉素灌胃对梗阻性黄疸(梗黄)大鼠应激性溃疡的影响及可能机制。方法雄性Wistar大鼠40只随机分4组:A组,结扎胆总管并以乳果糖和庆大霉素灌胃;B组,结扎胆总管并以葡萄糖灌胃;C组,假手术并用乳果糖和庆大霉素灌胃;D组,假手术并用葡萄糖灌胃。先行手术,14 d后再将4组大鼠分别行灌胃7 d,然后以水浸束缚应激诱导建立应激性溃疡模型,并分别检测门静脉血内毒素值和胃黏膜溃疡指数(UI,Guth评分)。结果A组门静脉血内毒素值及UI显著下降,B组门静脉血内毒素值及UI升高;C,D组门静脉血内毒素值及UI均处于较低水平。结论内毒素血症是加剧梗黄状态下应激性溃疡发生的重要原因之一。乳果糖和庆大霉素灌胃可降低血内毒素水平,有利于降低梗黄大鼠的总体应激性溃疡的发生率。
Objective To investigate the effect and mechanism of lactulose and gentamycin on gastric ulcer in obstructive jaundice rats. Methods Forty male Wistar rats were randomly divided into 4 groups: group A, common bile duct ligation and lactulose and gentamicin gavage; group B, common bile duct ligation and glucose gavage; group C, sham operation with lactulose And gentamicin gavage; D group, sham operation and intragastric administration of glucose. After 14 days, the rats in each group were given gavage for 7 days. Then the model of stress ulcer induced by water immersion restraint stress was established. The levels of endotoxin and gastric mucosal ulcer index (UI, Guth score). Results The values of endotoxin and UI in group A were significantly lower than those in group B. The values of endotoxin and UI in group B were higher than those in group B. The values of endotoxin and UI in group C and group D were all lower. Conclusions Endotoxemia is one of the important reasons for exacerbating the occurrence of stress ulcer in the state of. Lactulose and gentamicin gavage can reduce blood endotoxin levels, help to reduce the overall incidence of stress ulcer in rats.