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应用反转录－聚合酶链式反应（ＲＴ－ＰＣＲ）和３Ｈ－胸腺嘧啶核苷参入技术发现，在正常生理状态下，内皮素可与大鼠血管平滑肌细胞（ＶＳＭＣ）上内皮素Ａ型受体、内皮素Ｂ型受体结合，通过调控一氧化氮合成酶（ＮＯＳ）ｍＲＮＡ转录表达水平，从而调节ＶＳＭＣ的分裂和增殖。白细胞介素－１对ＶＳＭＣ中ＮＯＳ基因表达的促进作用和对ＶＳＭＣ分裂的影响，可能部分是通过内皮素及其受体这一途径完成的。
Reverse transcription-polymerase chain reaction (RT-PCR) and 3H-thymidine incorporation indicated that endothelin could interact with endothelin type A receptor in rat vascular smooth muscle cells (VSMCs) under normal physiological conditions Body and endothelin type B receptor, regulate the transcription and expression of nitric oxide synthase (NOS) mRNA to regulate the division and proliferation of VSMC. The effect of interleukin-1 on the expression of NOS gene in VSMCs and the effect on the division of VSMCs may be partially mediated by endothelin and its receptors.