论文部分内容阅读
用高效液相色谱方法测定47例长期口服胺碘酮的各类心律失常患者血清药物浓度。胶碘酮治疗心律失常的总有效率为89.3%。平均血清浓度于显效组、改善组和无效组分别为0.66、0.57、0.34μg/ml。服药时间超过半年者17例,其平均血浓度为0.58μg/ml,对血药浓度与疗效的关系及其指导临床用药的意义进行了讨论。
Serum drug concentrations in 47 patients with long-term oral amiodarone were measured by HPLC. The total effective rate of Gonadotropin treatment of arrhythmia was 89.3%. Mean serum concentration in the effective group, improved group and invalid group were 0.66,0.57,0.34μg / ml. Medication time of more than six months in 17 cases, the average blood concentration of 0.58μg / ml, the relationship between plasma concentration and efficacy and the significance of its guidance for clinical use were discussed.