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用MG系列鼠抗人胃癌单克隆抗体免疫酶法对直肠癌、良性肠道疾病及正常人血清中一组新的肿瘤相关抗原(MG-Ags)进行检测,并观察其手术前后血清中含量的变化,以探讨其在直肠癌诊断中的价值。以25名正常人血清MG-Ags检测OD值的均数加3个标准差之和,作为判断肿瘤的阳性阈值,直肠癌患者33例MG-Ags检出阳性率为69.7％,良性肠道疾病25例假阳性率仅为4％。对5例行直肠癌切除术的MG-Ags阳性病人,术后8～10天检测血清中MG-Ags水平明显降低。实验结果提示,MG～Ags检测对直肠癌具有较高的临床应用价值。
A new set of tumor-associated antigens (MG-Ags) in rectal cancer, benign bowel disease, and normal human serum was detected by MG mouse anti-human gastric cancer monoclonal antibody immunoenzymatic method, and its serum levels before and after surgery were observed. Changes to explore its value in the diagnosis of rectal cancer. The mean OD value of MG-Ags detected by 25 normal persons plus the sum of 3 standard deviations was used as a positive threshold for judging tumors. The positive rate of detection of MG-Ags in 33 patients with rectal cancer was 69.7%. Benign intestinal disease The false positive rate in 25 cases was only 4%. In 5 cases of MG-Ags positive patients undergoing resection of rectal cancer, serum MG-Ags levels were significantly reduced at 8 to 10 days after surgery. The experimental results suggest that MG-Ags detection has a high clinical application value for rectal cancer.