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目的检测IL-12和孕酮在多发性硬化(MS)患者中的水平,探讨男、女性多发性硬化患者存在的发病机制,比较男、女性MS患者在临床上发病的差异。方法采用酶联免疫(ELISA)法检测60例MS患者的脑脊液和40例患者血液中IL-12的水平,应用放射免疫法测定40例MS患者血液中孕酮的含量,并与40例正常对照组比较(以上标本男女各半)。结果男、女性MS患者血液中和脑脊液IL-12的含量明显高于正常对照组(P<0.01);女性患者血液中孕酮的含量明显低于正常对照组(P<0.01),男性患者血液中孕酮的含量与正常对照组差别不明显(P>0.05);女性患者血液中孕酮对IL-12的含量存在负相相关作用(r=-0.80,P<0.01),男性相关作用不明显(r=-0.38,P>0.05)。结论IL-12参与多发性硬化的发病过程;孕酮可能是男、女性患者发病差异性的原因之一。
Objective To detect the levels of IL-12 and progesterone in patients with multiple sclerosis (MS) and to explore the pathogenesis of multiple sclerosis in both men and women. To compare the clinical manifestations of men and women with MS. Methods The levels of IL-12 in the blood of 60 MS patients and 40 patients were measured by enzyme-linked immunosorbent assay (ELISA). The levels of progesterone in blood of 40 MS patients were determined by radioimmunoassay and compared with 40 normal controls Group comparison (more than half of the specimens men and women). Results The contents of IL-12 in blood and cerebrospinal fluid in MS patients were significantly higher than those in normal controls (P <0.01). The levels of progesterone in female patients were significantly lower than those in normal controls (P <0.01) The content of progesterone was not significantly different from that of the normal control group (P> 0.05). Progesterone in the blood of the female patients had a negative correlation with the content of IL-12 (r = -0.80, P <0.01) Significantly (r = -0.38, P> 0.05). Conclusion IL-12 is involved in the pathogenesis of multiple sclerosis. Progesterone may be one of the reasons for the different incidence of male and female patients.