论文部分内容阅读
本文分析了１９８６年７月至１９８８年７月初诊的９３例鼻咽癌患者颅神经受累放疗修复情况及１９８６年７月至１９８７年６月初治２７４鼻咽癌放疗后随访５年颅神经损伤情况。发现鼻咽癌患者中第Ｖ、ＶＩ对颅神经较易受累。经放疗后颅神经症状完全恢复的仅４４％。但放疗后的有少数逐渐恢复，影响颅神经修复的因素主要是病程和再次放疗。疗前病程长及鼻咽癌复发所致的颅神经损伤放疗恢复率极差。高能Ｘ线因鼻咽周围剂量区较高故颅神经损伤修复率高于６０Ｃｏ放疗。Ｐ值接近０．０５。而放疗所致的颅神经损伤主要与放疗剂量有关。当放疗剂量≥８０Ｇｙ及鼻咽癌复发再放疗的损伤率明显提高。放疗损伤与性别、分期，射线种类无关。年龄较大的损伤率较高，Ｐ值接近０．０５。我们认为治疗中应注意放疗设野及放疗剂量分布问题。对可能生存期较长的应避免高剂量点在正常组织中以提高生存质量。还必须注意放疗后３个月，半年也可能出现颅神经损伤。但必须排除复发的因素。
This article analyzes the repair of cranial nerve involvement in 93 cases of nasopharyngeal carcinoma newly diagnosed from July 1986 to July 1988 and the cranial nerve injury of 274 cases of nasopharyngeal carcinoma followed up for 5 years from July 1986 to June 1987 . Found in nasopharyngeal carcinoma in the V, VI of the cranial nerves are more susceptible. After radiotherapy cranial nerve symptoms completely restored only 44%. However, a small number of post-radiotherapy gradually restored, the main factors affecting the cranial nerve repair course of disease and re-radiotherapy. Long course of treatment and nasopharyngeal carcinoma recurrence caused by cranial nerve injury radiotherapy recovery rate was poor. High-energy X-ray due to the high dose area around the nasopharyngeal cranial nerve injury repair rate higher than 60Co radiotherapy. P value close to 0.05. The main cause of radiation-induced cranial nerve injury and radiation dose. When the radiotherapy dose ≥ 80Gy and nasopharyngeal carcinoma recurrence and radiation treatment injury rate was significantly increased. Radiotherapy injury and sex, stage, type of radiation has nothing to do. Older injury rate is higher, P value close to 0.05. We think that we should pay attention to radiation therapy and radiotherapy radiation dose distribution. For long-term survival should avoid high-dose point in normal tissue to improve the quality of life. Must also pay attention to 3 months after radiotherapy, six months may also occur cranial nerve injury. But you must rule out the recurrence of factors.