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目的:探讨中性粒细胞/淋巴细胞（NLR）和血小板/淋巴细胞（PLR）与2型糖尿病（T2DM）患者肾小管损伤的相关性。方法:收集2018年9月至2019年9月于中南大学湘雅三医院住院治疗的268例T2DM患者，根据尿白蛋白/肌酐比值（UACR），将其分为正常白蛋白尿组（UACR2.08, or β2-MG/Ucr>0.07 (AUC were 0.700, 0.679, 0.717, 0.702, 0.737, respectively; sensitivities were 75.29%, 85.87%, 80.88%, 83.74%, 85.59%, respectively) were all higher than those of PLR (AUC were 0.639, 0.639, 0.659, 0.644, 0.676, respectively; sensitivities were 58.05%, 75.00%, 63.24%, 65.04%, 58.56%, respectively) and hs-CRP (AUC were 0.597, 0.559, 0.618, 0.644, 0.653, respectively; sensitivities were 62.50%, 30.12%, 63.93%, 68.42%, 70.87%, respectively).n Conclusion:Both NLR and PLR are closely related to renal tubular injury in patients with T2DM, and NLR is superior to PLR or hs-CRP not only in reflecting glomerular damage but also in tubular injury.