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目的研究转化生长因子(TGF)、胱天蛋白酶、T细胞亚群、白细胞介素(IL)在慢性乙型肝炎患者中的变化及意义。方法选取62例慢性乙型肝炎患者为观察组,另选取体检健康者62例为对照组,检测并分析各项指标水平。结果观察组c-IAP1蛋白的阳性表达率、表达水平高于对照组,差异有统计学意义(P<0.05)。观察组外周血淋巴细胞、白细胞、T细胞、CD8~+T细胞、CD4~+T细胞、CD4~+CD28~+T细胞、CD8~+CD28~+T细胞计数以及NK细胞计数均明显低于对照组,差异有统计学意义(P<0.05);观察组外周血CD4~+CD28RA~+62L~+T细胞计数和比例较对照组减少,而CD4~+CD45RA-T细胞则较对照组增加,差异有统计学意义(P<0.05)。观察组IL-6、IL-8和IL-32的水平以及TGF-β1水平较对照组显著升高,差异有统计学意义(P<0.05)。结论 TGF、c-IAP1、T细胞亚群以及IL水平能有效监测慢性乙型肝炎的发生。
Objective To investigate the changes and clinical significance of transforming growth factor (TGF), caspases, T lymphocyte subsets and interleukin (IL) in chronic hepatitis B patients. Methods Sixty-two patients with chronic hepatitis B were selected as the observation group and 62 healthy people were selected as the control group. The levels of each index were detected and analyzed. Results The positive expression rate of c-IAP1 protein in the observation group was higher than that in the control group (P <0.05). The numbers of CD4 ~ + T cells, CD4 ~ + CD28 ~ + T cells, CD8 ~ + CD28 ~ + T cells and NK cells in the observation group were significantly lower than those of the T cells, CD8 + T cells, (P <0.05). The counts and the percentage of CD4 ~ + CD28RA ~ + 62L ~ + T cells in the peripheral blood of the observation group decreased as compared with the control group, while the CD4 ~ + CD45RA-T cells increased , The difference was statistically significant (P <0.05). The level of IL-6, IL-8 and IL-32 and the level of TGF-β1 in the observation group were significantly higher than those in the control group (P <0.05). Conclusion TGF, c-IAP1, T cell subsets and IL levels can effectively monitor the occurrence of chronic hepatitis B.