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目的探讨新诊断的2型糖尿病(T2DM)合并非酒精性脂肪性肝病(NAFLD)患者(T2DM+NAFLD组)血浆内脏脂肪素(Visfatin)表达水平及其与胰岛素敏感性(ISI)的关系。方法选取新诊断的T2DM患者94例,其中不伴NAFLD者46例,伴NAFLD者48例。取单纯NAFLD及正常体检者(NC组)各30例作为对照。观察其血浆Visfatin水平并计算其ISI。结果 T2DM+NAFLD组、T2DM组及NAFLD组血浆Visfatin浓度均高于NC组(P<0.05或P<0.01),但糖尿病亚组间比较差异无显著性(P>0.05)。血浆Visfatin浓度与空腹血糖、胰岛素抵抗呈正相关,与ISI呈负相关。结论新诊断的T2DM合并NAFLD者血浆Visfatin水平显著升高,其水平高表达除了类胰岛素样作用外,可能参与胰岛素增敏作用。
Objective To investigate the relationship between plasma visfatin (Visfatin) expression and insulin sensitivity (ISI) in patients with newly diagnosed type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD). Methods Totally 94 newly diagnosed T2DM patients were selected, including 46 without NAFLD and 48 with NAFLD. Take NAFLD simple and normal subjects (NC group) of 30 cases as a control. Observe the plasma Visfatin level and calculate its ISI. Results The plasma concentrations of Visfatin in T2DM + NAFLD, T2DM and NAFLD groups were significantly higher than those in NC group (P <0.05 or P <0.01), but there was no significant difference in diabetic subgroups (P> 0.05). Visfatin plasma concentration and fasting blood glucose, insulin resistance was positively correlated with ISI was negatively correlated. Conclusions Visfatin levels in newly diagnosed T2DM patients with NAFLD are significantly higher than those in NAFLD patients. Except for insulin-like activity, Visfatin may be involved in insulin sensitization.