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探讨双能X线骨密度仅（DEXA）对多发性骨髓瘤（MM）患者骨密度测定的临床价值，采用DEXA按照全身、腰椎、髋股骨三种部位和方法测定了18例初治的IgG型组（其中含7例X线骨骼检查阴性）和11例复治的未定型组MM患者的骨密度。结果，与对照组比较，IgG型组与未定型组的腰椎各部位及左右髋股骨大部分部位骨密度明显降低（P＜0．05），X线骨骼检查阴性的7例患者腰椎侧位与腰4侧位也明显下降（p＜0．05），分别为13％与14％。按国内MM分期标准，IgG型组中Ⅲ期患者的腰椎各部位及左右髋股骨大部分部位骨密度降于Ⅱ期（P〈0．05），其中侧位腰4降低21％（P＜0.01）。结果表明，DEXA骨密度尤其腰椎骨密度测定对MM患者的诊断、分期有重要价值。
To investigate the clinical value of dual-energy X-ray absorptiometry (DEXA) on bone mineral density in multiple myeloma (MM) patients. Eighteen cases of newly diagnosed IgG were measured by DEXA in accordance with the whole body, lumbar spine, and hip femur. The bone density of the group (which included 7 cases of X-ray skeletal examination negative) and 11 cases of retreatment of the undefined group MM patients. RESULTS: Compared with the control group, the BMD of the lumbar vertebrae and most of the left and right hip femurs in the IgG group and the unfixed group was significantly decreased (P<0.05). The lateral lumbar vertebrae of the 7 patients with negative X-ray skeletal examination were significantly different. The lateral position of the lumbar 4 was also significantly decreased (p<0.05), which was 13% and 14%, respectively. According to the domestic MM staging criteria, the bone density of the lumbar vertebrae and most of the left and right hip femurs of stage III patients in the IgG group decreased to stage II (P<0.05), and the lateral lumbar 4 decreased by 21% (P<0.01). ). The results show that DEXA bone density, especially lumbar spine BMD, is of great value in the diagnosis and staging of MM patients.