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目的 分析血液净化护理安全影响因素，同时总结有效的应对措施。方法 本文调查时间选择2018年1月至2019年8月，设置观察组：研究对象为在此期间来我院进行血液净化的28例出现护理安全的患者；设置对照组：研究对象为同期到我院进行血液净化且没有出现护理安全的28例患者。两组患者均配合针对性的血液净化护理，并对患者临床资料进行回顾性分析和总结，调查患者出现血液净化护理安全的因素，同时总结相对应的策略。结果 ①血液净化护理产生安全风险的单因素分析可得护士问题、患者因素、环境因素、护理质量管理因素、护理模式因素，差“,”Objective To analyze the influencing factors of blood purification nursing safety，and to summarize the effective countermeasures.Methods From January 2018 to August 2019，the investigation time of this paper was selected，and the observation group was set up: the research object was 28 patients who had nursing safety who came to our hospital for blood purification in this period;the control group was set up: the research object was 28 patients who came to our hospital for blood purification in the same period without nursing safety.Two groups of patients were cooperated with targeted blood purification nursing，and the clinical data of patients were retrospectively analyzed and summarized to investigate the safety factors of blood purification nursing，and summarize the corresponding strategies.Results(1)The single factors of blood purification nursing safety risk mainly included nurse problems，patient factors，environmental factors，nursing quality management factors，and nursing model factors(P＜0.05).(2)The multivariate regression analysis showed that Nurses\' problems，patient factors，environmental factors，nursing quality management factors，and nursing model factors are also independent risk factors for blood purification nursing safety risks(P＜0.05).(3)Physiological function of the two groups of patients before nursing there was no difference in the quality of life scores in 8 dimensions，including physiological function，physiological function，body pain，general health，energy，social function，emotional function，and mental health，and the difference was no statistically significant(P＞0.05).The physiological function of the observation group after nursing，the quality of life in the eight dimensions of physiological function，function physical physical pain，general health，energy，social function，emotional function，and mental health was significantly higher than that of the control group(P＜0.05).(4)The observation group(18 cases，accounting for 64.29%)the comfort level of patients was significantly higher than that of the control group(25 cases，accounting for 89.29%)(P＜0.05).Conclusion In the process of clinical blood purification，the factors that affect the nursing safety of patients come from many aspects.We need to deal with the related problems effectively，cooperate with the corresponding coping strategies，and comprehensively improve the nursing safety of patients with blood purification，which is worth promoting.