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目的探讨载脂蛋白B(ApoB)/载脂蛋白A1(ApoA1)比值与代谢综合征(MS)及其组分的关系。方法纳入709例重庆地区成年人,测定体重、身高、血压、腰围、空腹血浆葡萄糖(FPG)、空腹血清胰岛素(Fins)及血脂等,计算ApoB/ApoA1、BMI及胰岛素抵抗指数。结果 IR或MS患者,其ApoB/ApoA1比值显著增高;与低ApoB/ApoA1值人群相比,高ApoB/ApoA1值人群发生MS(OR=3.5)和IR(OR=2.3)的风险显著增加(P<0.001)。随MS组分数增加,ApoB/ApoA1比值逐渐增加(P<0.001)。结论 ApoB/ApoA1比值与IR、MS及其组分密切相关,ApoB/ApoA1比值增高是MS发生的重要标志。
Objective To investigate the relationship between the ratio of apolipoprotein B (ApoB) / apolipoprotein A1 (ApoA1) and metabolic syndrome (MS) and its components. Methods A total of 709 adults in Chongqing were enrolled in the study. Body weight, height, blood pressure, waist circumference, fasting plasma glucose (FPG), fasting serum insulin and serum lipids were measured to calculate ApoB / ApoA1, BMI and insulin resistance index. Results The ApoB / ApoA1 ratio was significantly increased in patients with IR or MS. The risk of developing MS (OR = 3.5) and IR (OR = 2.3) was significantly higher in high ApoB / ApoA1 patients than in low ApoB / ApoA1 patients <0.001). With the increase of MS group, the ratio of ApoB / ApoA1 gradually increased (P <0.001). Conclusion The ApoB / ApoA1 ratio is closely related to IR, MS and its components. The increased ApoB / ApoA1 ratio is an important marker of MS.