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目的 探讨高压氧(HBO)治疗新生儿缺氧缺血性脑病(HIE)的临床意义。方法 HBO治疗组70例，给予HBO及常规护脑，对症治疗。氧舱内压为0.02～0.03 MPa，稳压时间为30 min，每次50～60 min，每日1次，5次为1疗程，共2个疗程。对照组72例，给予常压下吸氧及同样护脑、对症治疗。HBO治疗前后行新生儿行为神经测定(NBNA)及头颅CT检查。结果 治疗后高压氧组中度、重度HIE患儿的NBNA评分分别为(36.07±0.92)，(34.52±1.53)；对照组分别为(32.35±0.92)，(30.37±1.95)。差异有显著性意义(P<0.01)。治疗后高压氧组头颅CT显示低密度脑叶数如下：0叶为67例，1～2叶为3例。对照组分别是：0叶为50例，1～2叶为17例。>2叶为5例，差异有显著性意义(P<0.05)。结论 NBNA是评估HBO治疗中重度HIE患儿近期疗效理想的方法之一。
Objective To investigate the clinical significance of hyperbaric oxygen (HBO) in neonates with hypoxic-ischemic encephalopathy (HIE). Methods 70 cases of HBO treatment group, given HBO and conventional brain protection, symptomatic treatment. Oxygen chamber pressure of 0.02 ~ 0.03 MPa, voltage regulation time of 30 min, each 50 ~ 60 min, day 1, 5 times for a course of treatment, a total of 2 courses. The control group of 72 cases, given atmospheric oxygen and the same protection brain, symptomatic treatment. Neonatal Behavioral Nerve Measurement (NBNA) and Head CT Examination before and after HBO Therapy. Results After treatment, the NBNA scores of hypercholesterolemic HIE group were (36.07 ± 0.92) and (34.52 ± 1.53), respectively; the control group were (32.35 ± 0.92) and (30.37 ± 1.95) respectively. The difference was significant (P <0.01). After treatment, hyperbaric oxygen group skull CT showed low-density brain lobes as follows: 0 leaves for 67 cases, 1 to 2 leaves for 3 cases. The control group were: 0 leaves 50 cases, 1 to 2 leaves 17 cases. > 2 leaves in 5 cases, the difference was significant (P <0.05). Conclusion NBNA is one of the methods to evaluate the recent efficacy of HBO in the treatment of severe HIE.