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目的:评价利尿剂(呋塞米与螺内酯联用)不同给药时间治疗晚期血吸虫病腹水患者的临床疗效。方法:选取2013年3月—2014年5月间接受治疗的晚期血吸虫病腹水患者200例,分为联用组和对照组(每组100例);联用组患者予不同给药时间的利尿剂治疗,对照组患者予常规服用利尿剂治疗,比较两组患者治疗后的临床疗效。结果:联用组患者伴外周水肿体质量减少为0.6~1 kg/d与患者无外周性水肿体质量下降为0.3~0.5 kg/d为67例,治疗有效率为94.00%;对照组患者伴外周性水肿体质量减少为0.6~1 kg/d与患者无外周性水肿体质量下降为0.3~0.5 kg/d为40例,治疗有效率为89.00%,两组患者治疗的有效率经统计学比较,其差异有统计学意义(P<0.05)。结论:不同时间给药时间对利尿剂治疗晚期血吸虫病腹水患者的疗效较为显著。
Objective: To evaluate the clinical efficacy of diuretics (furosemide combined with spironolactone) in patients with advanced schistosomiasis ascites treated with different administration time. Methods: Two hundred and seventy patients with advanced schistosomiasis ascites received treatment between March 2013 and May 2014 were enrolled in this study. The patients were divided into combined group and control group (100 cases in each group). Patients in combination group were given diuretic The patients in the control group were given routine diuretic therapy, and the clinical efficacy of the two groups was compared. Results: In the combined group, the reduction of body weight with peripheral edema was 0.6-1 kg / d and that of the patients without peripheral edema was decreased from 0.3-0.5 kg / d to 67 cases with the effective rate of 94.00%. The patients in the control group Peripheral edema reduction in body mass of 0.6 to 1 kg / d and no peripheral edema in patients with body mass decreased from 0.3 to 0.5 kg / d was 40 cases, the effective rate was 89.00%, the two groups of patients treated by the efficiency of statistical The difference was statistically significant (P <0.05). Conclusion: The effect of different time of dosing on patients with ascites caused by schistosomiasis in diarrhea is more significant.