论文部分内容阅读
年轻乳腺癌(≤35岁)发病率呈上升趋势,一般认为与年老乳腺癌相比更具侵袭性,预后差。占同期乳腺癌的5%～13%,主要发病危险因素是乳腺癌家族史阳性,并较多具有BRCA1/2基因突变。由于腺体致密,早期诊断存在一定困难。其具有更多不利的病理学及生物学特征。治疗上应重视全身综合治疗。本文就年轻乳腺癌的发病情况、危险因素、临床诊断、形态学及生物学特征、治疗等方面作一综述,以期早期发现及改善生存率。
The incidence of young breast cancer (≤35 years old) is on the rise, and is generally considered to be more aggressive than the older breast cancer with a poor prognosis. Accounting for 5% ~ 13% of breast cancer in the same period, the main risk factor is the positive family history of breast cancer, and more with BRCA1 / 2 gene mutations. Due to the dense glands, there are some difficulties in early diagnosis. It has more adverse pathological and biological features. Treatment should pay attention to systemic treatment. This article reviews the incidence of breast cancer, risk factors, clinical diagnosis, morphological and biological characteristics, treatment and other aspects of young breast cancer in order to early detection and improvement of survival.