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目的总结川崎病(KD)患儿的临床表现、冠状动脉病变,正确诊治KD。方法对2003年1月—2010年12月收治的98例KD的临床资料进行分析。结果①临床表现出现频率依次是:发热、黏膜改变、颈淋巴结肿大,球结膜充血、皮疹、四肢变化。②大剂量应用静脉注射免疫球蛋白(IVIg)1g/kg单剂、两剂及2g/kg单剂3组在冠状动脉病变恢复率及新病变发生率间无明显差异(P>0.05)。③治疗后4周冠状动脉扩张恢复情况:轻度18例完全恢复8例(44.4%),中度20例完全恢复5例(25.%),重度3例均未恢复。结论 KD是儿童获得性心血管病的重要病因,影响患儿的生存质量,要重视其早期诊断、早期治疗,也要重视远期随访。
Objective To summarize the clinical manifestations, coronary artery lesions in children with Kawasaki disease (KD) and to diagnose and treat KD correctly. Methods The clinical data of 98 cases of KD admitted from January 2003 to December 2010 were analyzed. Results ① The frequency of clinical manifestations followed: fever, mucosal changes, cervical lymph nodes, conjunctival hyperemia, rash, limbs changes. ② The high dose intravenous immunoglobulin (IVIg) 1g / kg single dose, two doses and 2g / kg single dose three groups in coronary artery disease recovery and the incidence of new lesions was no significant difference (P> 0.05). ③ The recovery of coronary artery dilation after 4 weeks of treatment: 8 cases (44.4%) were completely recovered in 18 cases with slight degree, 5 cases (25%) were moderately recovered in 20 cases and no severe cases were recovered in 3 cases. Conclusion KD is an important cause of childhood acquired cardiovascular disease, affecting children’s quality of life, we must pay attention to its early diagnosis and early treatment, but also pay attention to long-term follow-up.