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文献记载红霉素在pH 4以下迅即失效,pH 6～8稳定,pH 5以下经1小时效价显著降低。中国药典1977年版规定乳糖酸红霉素(下简称红霉素)可溶于萄葡糖注射液中滴注(下简称葡萄糖液),并规定葡萄糖液pH值为3.2～5.5。红霉素可因葡萄糖液的pH影响而降效,但未引起临床重视。为此,作者对本品溶解后的稳定性作了实验探讨,兹报告如下。实验方法 1.葡萄糖液pH值的测定方法:抽取本市销售及医院自制葡萄糖液32批,其中10%的18
Erythromycin has been reported to fail immediately below pH 4 with a pH of 6-8, and a significant reduction in titer of 1 hour below pH 5 has been reported. Chinese Pharmacopoeia 1977 edition provides erythromycin lactobionate (hereinafter referred to as erythromycin) soluble in glucose injection instillation (hereinafter referred to as glucose solution), and provides glucose solution pH value of 3.2 to 5.5. Erythromycin can be reduced due to the pH of glucose solution, but did not attract clinical attention. To this end, the authors made an experimental study of the stability of the dissolution of the goods, it is reported as follows. Experimental methods 1. Determination of glucose solution pH value: Extraction of the city’s sales and hospital homemade glucose solution 32 batches, of which 10% of 18