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世界上民间传说和传统医学经验用于生育调节的植物已有200余种,据Farnsworth1975年报告经实验动物筛选有抗生育作用的植物达145种。从植物中寻找避孕药日益受到重视,仅印度就初筛了约400种,其中少数植物对大鼠有60%的抗生育活性。吴氏对国外的研究作过综述。但近年又有很大进展,现介绍如下。一、男用避孕植物药的研究棉酚:自80年代国外对棉酚主要从细胞水平研究其作用机制;从药代动力学和毒理学及分子或酶水平研究其生化作用机制。对后者研究结果有的尚不一致。棉酚的抗生育作用和对细胞的毒性依动物种属有所不同。除其本身的毒性外,所含杂质毒性也很大,棉酚在体外能抑制豚鼠精子获能,10~(-4)M棉
There are more than 200 species of plants used for fertility regulation in the world based on folklore and traditional medical experience. According to the Farnsworth Report of 1975, 145 species of plants and animals have been successfully commissioned for reproductive activities. Looking for contraceptives from plants is gaining more and more attention. About 400 species have been screened in India alone, and a few of them have a 60% anti-fertility activity in rats. Wu made a review of foreign studies. However, great progress has been made in recent years and the following is introduced below. First, the study of male contraceptives Gossypol: Since the 1980s, foreign gossypol mainly from the cellular level to study its mechanism of action; pharmacokinetics and toxicology and molecular or enzyme level to study its biochemical mechanism. The results of the latter are not the same. Gossypol’s anti-fertility and toxicity to cells vary by species. In addition to its own toxicity, the impurities contained are also very toxic, gossypol can inhibit guinea pig sperm capacitation in vitro, 10 ~ (-4) M cotton