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本文报道了药物治疗双盲法科研中安慰剂组的73例流行性出血热病人,分析了其内生肌酐清除率(Ccr)在不同的病型、病期中的自然动态变化特点及其与尿素氮(BUN)、血肌酐(Scr)的相关性,并与正常人相比。结果显示:在病型中,轻型患者的 Ccr 即较正常人为低(P<0.05),病型愈严重,Ccr 降低愈明显,各型之间差异有显著性(P<0.05);Ccr 与性别无关(P<0.05)。各型的Ccr 与 BUN,Scr 呈负相关(P<0.05)。在病期中,发热期患者 Ccr 低于正常人(P<0.05),至低血压休克期最低,移行期开始回升,恢复期仍有70.9％(56/79例次)检测未恢复正常。结果提示 Ccr 与流行性出血热肾功能损害程度及其预后有密切关系。
In this paper, 73 patients with epidemic hemorrhagic fever in placebo group treated with double-blind method were studied. The natural dynamic changes of endogenous creatinine clearance rate (Ccr) in different types and stages of disease were analyzed. Nitrogen (BUN), serum creatinine (Scr) were compared and compared with normal subjects. The results showed that in patients with mild disease, the Ccr of patients with mild type was lower than that of normal people (P <0.05). The more serious the type of disease was, the more obvious the decrease of Ccr was, the difference between each type was significant (P <0.05) Not related (P <0.05). Each type of Ccr was negatively correlated with BUN and Scr (P <0.05). During the fever period, Ccr was lower in patients with fever than in normal people (P <0.05). The duration of hypotension was the lowest in shock stage and started to recover in transitional period. However, 70.9% (56/79 cases) of recovery did not return to normal. The results suggest that Ccr is closely related to the degree of renal dysfunction and prognosis of epidemic hemorrhagic fever.