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辐射诱导肿瘤细胞的凋亡是近年来放射生物学研究的热点，为了进一步探讨辐射诱导肿瘤细胞凋亡的机制，采用光镜、电镜及ＤＮＡ琼脂糖凝胶电泳法观察Ｘ射线诱导多形性胶质母细胞瘤细胞系凋亡的特征。结果表明：①剂量率和分次照射组（１０Ｇｙ）诱导出典型细胞凋亡的特征（如凋亡小体，ＤＮＡ梯状带等）。②剂量诱导肿瘤细胞凋亡，高剂量导致肿瘤细胞坏死。③凋亡出现时间因组织细胞类型的不同而各有差异。④射线诱导肿瘤细胞的凋亡以分裂期凋亡为主。此结果将为临床放射治疗多形性胶质母细胞瘤的研究提供一定的理论依据
Radiation-induced apoptosis of tumor cells is a hot spot in radiobiological research in recent years. In order to further explore the mechanism of radiation-induced apoptosis in tumor cells, X-ray induced polymorphs Apoptosis of glioblastoma cell lines. The results showed that: (1) The dose-rate and fractionated irradiation group (10Gy) induced typical apoptosis characteristics (such as apoptotic bodies, DNA ladder, etc.). ② dose-induced tumor cell apoptosis, high-dose lead to tumor cell necrosis. ③ Apoptosis occurs due to different types of tissue cells and have different. ④ radiation-induced apoptosis of tumor cells to divide the main apoptosis. This result will provide a theoretical basis for the study of clinical radiotherapy of glioblastoma multiforme